Discovery Life Sciences & Precision Instruments

You’ve eliminated every variable except this one.

In NGS platforms, flow cytometers, HPLC systems, and lab-on-chip devices, contamination doesn’t fail loudly. It produces variance. Unexplained assay inconsistency, signal-to-noise degradation, repeated experiments that should agree but don’t. The root cause is rarely traced to the seal surface – because what is residing on the seal surface has never been measured.

bioburden by microscope analysis

CCD and Assay Variance

Cyclic Contamination DisplacementTM (CCD) is the mechanism. Every pressure cycle, thermal gradient, and mechanical event expands the effective wetted area of a seal 3:1 to 8:1 beyond its static footprint. Contamination is released cumulatively. In a precision fluid-path instrument, the result is not a hard failure — it is baseline drift, reproducibility degradation, and signal variance that resists root-cause attribution.

Contamination Classes —Life Sciences

  • Talc (1–20 µm) mold release agent, anti tac agent, compounding filler
  • Carbon black (0.01–100µm) compounding filler pervasive to rubber molding factories
  • Skin squames (20–50 µm)
  • Sebum (film)
  • Textile fibers (50–2,000 µm+)

These are just 5 of 11 contamination classes which act alone or in agglomerations creating risk of HPLC ghost signals, assay failure, and LOC capillary channel obstruction. Read the full technical white paper for the complete taxonomy and impact of all 11 classes on the Intelligence page.

Discovery Life Sciences R&D/Applications Engineers

Discovery Life Sciences Lab Managers & Core Facility Operators

Discovery Life Sciences Instrument OEM Engineers & PMs

VeriClean Seals™ – A Specifiable Cleanliness Parameter

For instrument OEMs, VeriClean Seals™ represent the first opportunity to specify seal surface cleanliness as a product parameter — backwards compatible with existing BOM specs, no platform redesign required. A laboratory instrument seal supplier with documented cleanliness data is a new category. For lab managers and core facility operators, the VCQ delivers fluid path seal reproducibility data on the seals currently in your instruments.

Available as seals for analytical instruments, NGS platform seal components, seals for genomics instruments, seals for HPLC systems, flow cytometers, and lab-on-chip fluid paths. ISO Class 7 cleanroom processed. Particle-measured from ≥1.3 µm. The only supplier that measures,
reduces, and documents particulate contamination on elastomeric seals before they enter your system.